Investigation of Pharmacological Properties of Synsepalum Dulcificum for Myocardial Protection
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DOI:
https://doi.org/10.5281/zenodo.10368647Keywords:
Myocardial Protection, Synsepalum Dulcificum, Miracle Fruit, Pharmacological EffectsAbstract
The Synsepalum Dulcificum plant species, also known as the Miracle Fruit, has been used traditionally for centuries for its medicinal properties. This plant species is known to have various pharmacological properties that can be used to protect the heart muscle. Myocardial protection is of great importance in both heart diseases and cardiovascular surgery. This article discusses the pharmacological properties of S Dulcificum and its potential therapeutic benefits for myocardial protection.
It is stated that the S Dulcificum plant species has the potential to protect the myocardium and prevent myocardial infarction. Extracts of the leaves contain lycopene, which has a protective effect against cancer. It also contains polyphenols with antioxidant and antimicrobial properties. It has been stated that this type of herb can be used to prevent the accumulation of cancer-causing agents in the body and also reduce the risk of heart disease. Additionally, it may support the activity of antioxidant enzymes and block the action of fibrinolytic inhibitors, thus reducing the risk of heart damage. Additionally, S Dulcificum can protect the myocardium through the phytosynthesis of AgNPs, depending on its concentration.
Overall, this article aims to provide a comprehensive overview of the pharmacological properties of S Dulcificum and its potential therapeutic benefits for myocardial protection. Thus, we think that this article will contribute to the existing literature on the use of natural products for medical purposes and can be a source of in vivo and in vitro studies on myocardial protection, especially in cardiovascular surgery.
References
He Z, Tan J, Abbasiliasi S, Lai O, Tam Y. Phytochemicals, nutritionals and antioxidant properties of miracle fruit Synsepalum dulcificum. Industrial Crops and Products. 2026;86(2026):87-94. https://doi.org/10.1016/j.indcrop.2016.03.032
Du L, Shen Y, Zhang X, Prinyawiwatkul W, Xu Z. Antioxidant-rich phytochemicals in miracle berry ( Synsepalum dulcificum ) and antioxidant activity of its extracts. Food Chemistry. 2014;153(2014): 279-284. https://doi.org/10.1016/j.foodchem.2013.12.072
Jian H, Qiao F, Chen J, He N. Physicochemical Characterisation of Polysaccharides from the Seeds and Leaves of Miracle Fruit (Synsepalum dulcificum) and Their Antioxidant and α-Glucosidase Inhibitory Activities In Vitro. Journal of Chemistry. 2017:9 Article ID:8948639. https://doi.org/10.1155/2017/8948639
Shi Y-C, Lin K-S, Jhai Y-F, Lee B-H, Han Y, Cui Z, Hsu W-H, Wu S-C. Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent. Molecules. 2016;21(2):140. https://doi.org/10.3390/molecules21020140
Swamy K, Hadi S, Sekaran M, Pichika MR. The Clinical Effects of Synsepalum dulcificum: A Review. Journal of Medicinal Food. 2014;17(11):1165-1169. http://doi.org/10.1089/jmf.2013.3084
Obafemi T, Onasanya A, Adeoye A, et al. Protective effect of methanolic and flavonoid-rich leaf extracts of Synsepalum dulcificum (Danielli) on lead-acetate-induced toxicity in Wistar albino rats. Journal of Applied Pharmaceutical Science. 2029;9(5):065-072. https://doi.org/10.7324/JAPS.2019.90508
Lateef A, Ojo SA, Elegbede JA, Akinola PO, Akanni EO. (2018). Nanomedical Applications of Nanoparticles for Blood Coagulation Disorders. In: Dasgupta, N., Ranjan, S., Lichtfouse, E. (eds) Environmental Nanotechnology. Environmental Chemistry for a Sustainable World. Springer. 2028;14: 243–277. https://doi.org/10.1007/978-3-319-76090-2_8
Ma F-Y, Zhang X-M, Li Y, Zhang M, Tu X-H, Du L-Q. Identification of phenolics from miracle berry (Synsepalum dulcificum) leaf extract and its antiangiogenesis and anticancer activities. Front. Nutr. 2022;9:970019. https://doi.org/10.3389/fnut.2022.970019
Wang L, Lv M, An J, et al. Botanical characteristics, phytochemistry and related biological activities of Rosa roxburghii Tratt fruit, and its potential use in functional foods: A review. Food & Function. 2023;4(12):1432-1451. https://doi.org/10.1039/D0FO02603D
Achigan-Dako EG, Tchokponhoué DA, N’Danikou S, et al. Current knowledge and breeding perspectives for the miracle plant Synsepalum dulcificum (Schum. et Thonn.) Daniell. Genet Resour Crop Evol. 2015;62:465-476. https://doi.org/10.1007/s10722-015-0225-7
Haddad S, Mohammad M, Raafat K, Saleh FA. Antihyperglycemic and hepatoprotective properties of miracle fruit (Synsepalum dulcificum) compared to aspartame in alloxan-induced diabetic mice. Journal of Integrative Medicine. 2020;18(6):514-521. https://doi.org/10.1016/j.joim.2020.09.001
Wang J, Shao S, Huang R, Wu S. Chemical constituents and their antioxidant activities from the leaves of Synsepalum dulcificum. Natural Product Research. 2021;35(24):6141-6146. https://doi.org/10.1080/14786419.2020.1830394
Obafemi T, Olaleye M, Akinmoladun A. Antidiabetic property of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) leaf extracts in fructose-fed streptozotocin-injected rats via anti-inflammatory activity and inhibition of carbohydrate metabolizing enzymes. Journal of Ethnopharmacology. 2019;244: 112124. https://doi.org/10.1016/j.jep.2019.112124
Yang Y, Shi CY, Xie J, Dai JH, He SL, Tian Y. Identification of Potential Dipeptidyl Peptidase (DPP)-IV Inhibitors among Moringa oleifera Phytochemicals by Virtual Screening, Molecular Docking Analysis, ADME/T-Based Prediction, and In Vitro Analyses. Molecules. 2020;25(1):189. https://doi.org/10.3390/molecules25010189
Obafemi TO, Akinmoladun AC, Olaleye MT, Agboade SO, Onasanya AA. Antidiabetic potential of methanolic and flavonoid-rich leaf extracts of Synsepalum dulcificum in type 2 diabetic rats. Journal of Ayurveda and Integrative Medicine. 2017;8(4):238-246. https://doi.org/10.1016/j.jaim.2017.01.008
Chen C, Wu P, Huang T, et al. The sour taste-modifying protein (miraculin), tyrosinase inhibitors and antioxidants from Synsepalum dulcificum. Current Nutrition & Food Science. 2009;5(3):172-179. https://doi.org/10.2174/157340109789007108
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Castenmiller J, et al. Safety of dried fruits of Synsepalum dulcificum as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2021;19(6):e06600. Published 2021 Jun 11. https://doi.org/10.2903/j.efsa.2021.6600
Gorin S, Wakeford C, Zhang G, Sukamtoh E, Matteliano CJ, Finch AE. Beneficial effects of an investigational wristband containing Synsepalum dulcificum (miracle fruit) seed oil on the performance of hand and finger motor skills in healthy subjects: A randomized controlled preliminary study. Phytother Res. 2018;32(2):321-332. . https://doi.org/10.1002/ptr.5980
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