Genetic Factors in Heart Diseases
Review
DOI:
https://doi.org/10.5281/zenodo.10404972Keywords:
Heart Diseases, Genetics, FactorAbstract
Heart diseases are a growing problem worldwide and cause millions of deaths each year. Although lifestyle factors such as diet and exercise are known to contribute to the risk of heart disease, genetic factors also play an important role. This article explores the genetic risk factors associated with heart disease and how genetic mutations may cause these conditions.
Heart diseases are a major public health problem worldwide and are responsible for serious morbidity and mortality. While lifestyle factors such as smoking, malnutrition and lack of physical activity are known to contribute to the development of heart diseases, recent research also highlights the role of genetic factors in its pathogenesis. Understanding the genetic basis of heart diseases, the interaction between genetic predisposition and environmental factors, and the ethical consequences of genetic tests for heart diseases are important research areas.
As a result, genetic factors play an important role in the pathogenesis of heart diseases. Although our understanding of the genetic basis of heart disease is incomplete, recent research has identified critical biological pathways involved in the development of heart disease. The interaction between genetic predisposition and environmental and lifestyle factors is an important consideration in the prevention and treatment of heart diseases. Finally, the ethical implications of genetic testing for heart disease highlight the importance of careful consideration of these issues in the use of genetic testing in clinical practice.
References
Pierpont ME, Brueckner M, Chung WK, et al. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association [published correction appears in Circulation. 2018 Nov 20;138(21):e713]. Circulation. 2018;138(21):e653-e711. doi:10.1161/CIR.0000000000000606
Zaidi S, Brueckner M. Genetics and Genomics of Congenital Heart Disease. Circ Res. 2017;120(6):923-940. doi:10.1161/CIRCRESAHA.116.309140
Flowers E, Froelicher ES, Aouizerat BE. Gene-environment interactions in cardiovascular disease. Eur J Cardiovasc Nurs. 2012;11(4):472-478. doi:10.1016/j.ejcnurse.2011.06.001
Institute of Medicine (US) Committee on Assessing Interactions Among Social, Behavioral, and Genetic Factors in Health; Hernandez LM, Blazer DG, editors. Washington (DC): National Academies Press (US); 2006.
Carey RM, Muntner P, Bosworth HB, Whelton PK. Prevention and Control of Hypertension: JACC Health Promotion Series. J Am Coll Cardiol. 2018;72(11):1278-1293. doi:10.1016/j.jacc.2018.07.008
Institute of Medicine (US) Committee on Assessing Genetic Risks; Andrews LB, Fullarton JE, Holtzman NA, et al., editors. Washington (DC): National Academies Press (US); 1994.
Fulda KG, Lykens K. Ethical issues in predictive genetic testing: a public health perspective. J Med Ethics. 2006;32(3):143-147. doi:10.1136/jme.2004.010272
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